anti-Beclin 1 antibody (Beclin 1, Autophagy Related) (full length)

Details for Product anti-BECN1 Antibody No. ABIN658976
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Antigen
Synonyms beclin-1, atg6, vps30, beclin1, Beclin-1, becn1, zgc:73097, ATG6, VPS30, 4921513J16Rik, 5430417M23Rik, Atg6
Epitope
full length
(40), (19), (14), (12), (12), (12), (12), (12), (11), (11), (7), (7), (7), (6), (6), (6), (4), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(292), (89), (61), (20), (18), (17), (16), (11), (6), (3), (1), (1), (1)
Host
Mouse
(228), (65), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
This Beclin 1 antibody is un-conjugated
(18), (17), (17), (17), (17), (17), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(240), (117), (115), (57), (50), (47), (24), (22), (19), (14), (10), (6), (3), (1), (1)
Pubmed 5 references available
Quantity 0.1 mL
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Immunogen This BECN1 Monoclonal antibody was raised using purified His-tagged recombinant full length human Autophagy BECN1.
Clone 117CT2-5-1-1
Isotype IgM
Specificity This BECN1 Monoclonal antibody was raised using purified His-tagged recombinant full length human Autophagy BECN1.
Purification Ascites
Alternative Name BECN1 (BECN1 Antibody Abstract)
Background Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).
Synonyms: BECN1, ATG6, VPS30, beclin1, ATG6 autophagy related 6 homolog, beclin 1 (coiled-coil, moesin-like BCL2 interacting protein), beclin 1 (coiled-coil, moesin-like BCL2-interacting protein), beclin-1, coiled-coil myosin-like BCL2-interacting protein
Molecular Weight 51765 DA
Gene ID 8678
UniProt Q14457
Research Area Cell Signaling, Cell Structure, Autophagy
Application Notes WB = 1:100-400, IHC (p) = 1:50-100, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Buffer Crude ascites with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Beclin 1, Autophagy Related (BECN1) (full length) antibody Western blot analysis of anti-BECN1 Monoclonal Antibody in Jurkat cell line lysates ...
anti-Beclin 1, Autophagy Related (BECN1) (full length) antibody (2) Formalin-fixed and paraffin-embedded human brain with BECN1 Monoclonal Antibody, whic...
anti-Beclin 1, Autophagy Related (BECN1) (full length) antibody (3) Immunofluorescence analysis of BECN1 Monoclonal Antibody with paraffin-embedded human...
Background publications Metzger, Saukko, Van Che et al.: "Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7." in: Human genetics, Vol. 128, Issue 4, pp. 453-9, 2010 (PubMed).

Niu, Cheng, Ren et al.: "Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis." in: FEBS letters, Vol. 584, Issue 16, pp. 3519-24, 2010 (PubMed).

Jaeger, Pickford, Sun et al.: "Regulation of amyloid precursor protein processing by the Beclin 1 complex." in: PLoS ONE, Vol. 5, Issue 6, pp. e11102, 2010 (PubMed).

Li, Chen, Wu et al.: "Genetic and epigenetic silencing of the beclin 1 gene in sporadic breast tumors." in: BMC cancer, Vol. 10, pp. 98, 2010 (PubMed).

Sun, Liu, Jin et al.: "Over-expression of the Beclin1 gene upregulates chemosensitivity to anti-cancer drugs by enhancing therapy-induced apoptosis in cervix squamous carcinoma CaSki cells." in: Cancer letters, Vol. 294, Issue 2, pp. 204-10, 2010 (PubMed).

Validation Images
Catalog No. ABIN658976
291.50 $
Plus shipping costs $45.00
Quantity
Price
0.1 mL
291.50 $

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