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Beclin 1 antibody (Beclin 1, Autophagy Related) (full length)

Details for Product anti-BECN1 Antibody No. ABIN658976, Supplier: Log in to see
Antigen
  • 4921513J16Rik
  • 5430417M23Rik
  • atg6
  • ATG6
  • Atg6
  • beclin-1
  • Beclin-1
  • beclin1
  • becn1
  • VPS30
  • vps30
  • zgc:73097
Epitope
full length
34
32
19
14
13
13
13
11
11
9
8
8
8
6
6
6
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
358
103
88
14
13
11
10
6
5
3
2
1
1
1
Host
Mouse
288
74
4
Clonality (Clone)
Monoclonal ()
Conjugate
This Beclin 1 antibody is un-conjugated
20
19
19
19
19
19
4
4
4
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
285
154
126
58
56
50
27
17
16
11
6
3
2
1
Supplier
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Immunogen This BECN1 Monoclonal antibody was raised using purified His-tagged recombinant full length human Autophagy BECN1.
Clone 117CT2-5-1-1
Isotype IgM
Specificity This BECN1 Monoclonal antibody was raised using purified His-tagged recombinant full length human Autophagy BECN1.
Purification Ascites
Alternative Name BECN1 (BECN1 Antibody Abstract)
Background Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).
Synonyms: BECN1, ATG6, VPS30, beclin1, ATG6 autophagy related 6 homolog, beclin 1 (coiled-coil, moesin-like BCL2 interacting protein), beclin 1 (coiled-coil, moesin-like BCL2-interacting protein), beclin-1, coiled-coil myosin-like BCL2-interacting protein
Molecular Weight 51765 DA
Gene ID 8678
UniProt Q14457
Research Area Cell Signaling, Cell Structure, Autophagy
Application Notes WB = 1:100-400, IHC (p) = 1:50-100, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Buffer Crude ascites with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Beclin 1 antibody (Beclin 1, Autophagy Related) (full length) (ABIN658976) Western blot analysis of anti-BECN1 Monoclonal Antibody in Jurkat cell line lysates ...
Immunohistochemistry (IHC) image for anti-Beclin 1 antibody (Beclin 1, Autophagy Related) (full length) (ABIN658976) Formalin-fixed and paraffin-embedded human brain with BECN1 Monoclonal Antibody, whic...
Immunofluorescence (IF) image for anti-Beclin 1 antibody (Beclin 1, Autophagy Related) (full length) (ABIN658976) Immunofluorescence analysis of BECN1 Monoclonal Antibody with paraffin-embedded human...
Background publications Metzger, Saukko, Van Che, Tong, Puder, Riess, Nguyen: "Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7." in: Human genetics, Vol. 128, Issue 4, pp. 453-9, 2010

Niu, Cheng, Ren, Yang: "Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis." in: FEBS letters, Vol. 584, Issue 16, pp. 3519-24, 2010

Jaeger, Pickford, Sun, Lucin, Masliah, Wyss-Coray: "Regulation of amyloid precursor protein processing by the Beclin 1 complex." in: PLoS ONE, Vol. 5, Issue 6, pp. e11102, 2010

Li, Chen, Wu, Jin, Xia, Liu: "Genetic and epigenetic silencing of the beclin 1 gene in sporadic breast tumors." in: BMC cancer, Vol. 10, pp. 98, 2010

Sun, Liu, Jin, Lin, Yang, Sui, Shi: "Over-expression of the Beclin1 gene upregulates chemosensitivity to anti-cancer drugs by enhancing therapy-induced apoptosis in cervix squamous carcinoma CaSki cells." in: Cancer letters, Vol. 294, Issue 2, pp. 204-10, 2010