Paired Box 6 (PAX6) antibody

Antigen: Paired Box 6 (PAX6)

Synonyms: AN, AN2, MGDA, WAGR, D11S812E, MGC17209, Dey, Sey, AEY11, Pax-6, Gsfaey11, 1500038E17Rik, pax-6, an2, mgda, wagr, pax6a, xpax6, XLPAX6, MGC52531, PAX6, pax6, pax6b, PAX-6

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN659068

Additional Information

Alternative name: PAX6

Gene ID: 5080

UniProt: NP_000271.1, NP_001595.2, P26367, NP_001121084.1

Immunogen: This PAX6 Monoclonal antibody was raised using purified His-tagged recombinant human PAX6.

Format: Ascites

Isotype: IgM, kappa chain

Description: Other names: Paired box protein Pax-6,PAX6,AN2

Characteristics: Mouse Monoclonal Antibody (Mab)

Specificity: This PAX6 Monoclonal antibody was raised using purified His-tagged recombinant human PAX6.

Molecular Weight: 46683 DA

Comments:

Background: This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding either the same or different isoform have been found for this gene. [provided by RefSeq].

Application Details

Application Notes: The suggested dilution is: ELISA~~1:1000 Western blotting~~ 1:500~16000

Concentration: Crude ascites

Buffer: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Ubiquitin-related antibodies, Translation Factors, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Cell Structure

Restrictions: For Research Use only

Publications

Product: Gosmain, Marthinet, Cheyssac et al.: "Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function." in: The Journal of biological chemistry, Vol. 285, Issue 43, pp. 33381-93, 2010 (PubMed).

Vuzman, Polonsky, Levy: "Facilitated DNA search by multidomain transcription factors: cross talk via a flexible linker." in: Biophysical journal, Vol. 99, Issue 4, pp. 1202-11, 2010 (PubMed).