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Paired Box 6 (PAX6) antibody

Details for Product No. ABIN659068
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Antigen
Synonyms
AN, AN2, D11S812E, MGDA, WAGR, pax-6, Pax-6, XLPAX6, an2, mgda, pax6, pax6b, wagr, xpax6, PAX-6, PAXZF-A, Pax6.1, cb280, fc20e07, pax-a, pax[zf-a], paxzfa, wu:fc20e07, zfpax-6a, zfpax-6b, pax6a, MGC52 ... show more
AN, AN2, D11S812E, MGDA, WAGR, pax-6, Pax-6, XLPAX6, an2, mgda, pax6, pax6b, wagr, xpax6, PAX-6, PAXZF-A, Pax6.1, cb280, fc20e07, pax-a, pax[zf-a], paxzfa, wu:fc20e07, zfpax-6a, zfpax-6b, pax6a, MGC52531, PAX6 show less
Reactivity
Human
(95), (36), (31), (15), (14), (14), (6), (6), (2), (1)
Host
Mouse
(74), (23), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(87), (54), (23), (19), (15), (10), (8), (7), (4), (2), (1)
Pubmed 2 references available
Quantity 0.1 mL
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Catalog No. ABIN659068
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This PAX6 Monoclonal antibody was raised using purified His-tagged recombinant human PAX6.
Clone 193CT15-2-2
Isotype IgM, kappa
Specificity This PAX6 Monoclonal antibody was raised using purified His-tagged recombinant human PAX6.
Predicted Reactivity Cow (Bovine),Mouse (Murine)
Purification Ascites
Alternative Name PAX6
Background This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding either the same or different isoform have been found for this gene. [provided by RefSeq].
Synonyms: Paired box protein Pax-6,PAX6,AN2
Molecular Weight 46683 DA
Gene ID 5080
UniProt NP_000271.1, NP_001595.2, P26367, NP_001121084.1
Research Area Ubiquitin-related antibodies, Translation Factors, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:500-16000, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Buffer Crude ascites with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Paired Box 6 (PAX6) antibody PAX6 western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the PAX6 antibody detected the PAX6 protein (arrow).
anti-Paired Box 6 (PAX6) antibody (2) Confocal immunofluorescent analysis of PAX6 Antibody (Ascites) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-mouse lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue).
Background publications Gosmain, Marthinet, Cheyssac et al.: "Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function." in: The Journal of biological chemistry, Vol. 285, Issue 43, pp. 33381-93, 2010 (PubMed).

Vuzman, Polonsky, Levy: "Facilitated DNA search by multidomain transcription factors: cross talk via a flexible linker." in: Biophysical journal, Vol. 99, Issue 4, pp. 1202-11, 2010 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN659068
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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