Paired Box 6 (PAX6) antibody

Details for Product No. ABIN659069
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Antigen
Reactivity
Human
(100), (35), (33), (15), (14), (14), (6), (6), (2), (1)
Host
Mouse
(78), (25), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(95), (51), (24), (20), (18), (10), (9), (8), (4), (4), (3), (1)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN659069
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Immunogen This PAX6 monoclonal antibody is generated from mouse immunized with PAX6 recombinant protein.
Clone 193CT15-2-2
Isotype IgM, kappa
Specificity This PAX6 monoclonal antibody is generated from mouse immunized with PAX6 recombinant protein.
Predicted Reactivity Cow (Bovine),Mouse (Murine)
Purification This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
Alternative Name PAX6
Background This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding either the same or different isoform have been found for this gene. [provided by RefSeq].
Synonyms: Paired box protein Pax-6,PAX6,AN2
Molecular Weight 46683 DA
Gene ID 5080
NCBI Accession NP_001121084, NP_001595, NP_000271
UniProt P26367
Research Area Ubiquitin-related antibodies, Translation Factors, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:100-1000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Paired Box 6 (PAX6) antibody PAX6 Antibody western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the PAX6 antibody detected the PAX6 protein (arrow).
Background publications Gosmain, Marthinet, Cheyssac et al.: "Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function." in: The Journal of biological chemistry, Vol. 285, Issue 43, pp. 33381-93, 2010 (PubMed).

Vuzman, Polonsky, Levy: "Facilitated DNA search by multidomain transcription factors: cross talk via a flexible linker." in: Biophysical journal, Vol. 99, Issue 4, pp. 1202-11, 2010 (PubMed).

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