Eukaryotic Translation Initiation Factor 4E Family Member 2 (EIF4E2) antibody

Details for Product No. ABIN659116
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Antigen
Synonyms EIF4E2, id:ibd1007, zgc:110542, zgc:158544, MGC115622, 4E-LP, 4EHP, EIF4EL3, IF4e, Eif4el3, 2700069E09Rik, AI036339, AV129531, D0H0S6743E
Reactivity
Human
(59), (4), (4), (1), (1), (1), (1)
Host
Mouse
(32), (27)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB)
(58), (27), (14), (8), (7), (3), (1)
Pubmed 4 references available
Quantity 400 µL
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Catalog No. ABIN659116
291.50 $
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Immunogen This EIF4E2 monoclonal antibody is generated from mouse immunized with EIF4E2 recombinant protein.
Clone 225CT3-1-3
Isotype IgG1, kappa
Specificity This EIF4E2 monoclonal antibody is generated from mouse immunized with EIF4E2 recombinant protein.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name EIF4E2
Background EIF4E2 recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
Synonyms: Eukaryotic translation initiation factor 4E type 2,EIF4E2,EIF4EL3
Molecular Weight 28362 DA
Gene ID 9470
NCBI Accession NP_004837
UniProt O60573
Research Area Translation Factors, Signaling, Protein Modifications, Chromatin, Cell Structure
Application Notes WB = 1:100-250
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Eukaryotic Translation Initiation Factor 4E Family Member 2 (EIF4E2) antibody EIF4E2/MB10227 antibody western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the EIF4E2/MB10227 antibody detected the EIF4E2/MB10227 protein (arrow).
Background publications Rosettani, Knapp, Vismara et al.: "Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms." in: Journal of molecular biology, Vol. 368, Issue 3, pp. 691-705, 2007 (PubMed).

Zuberek, Kubacka, Jablonowska et al.: "Weak binding affinity of human 4EHP for mRNA cap analogs." in: RNA (New York, N.Y.), Vol. 13, Issue 5, pp. 691-7, 2007 (PubMed).

Venkatesan, Rual, Vazquez et al.: "An empirical framework for binary interactome mapping...." in: Nature methods, Vol. 6, Issue 1, pp. 83-90, 2008 (PubMed).

Watkins, Rukazenkov: "Response to 'Clinical outcomes in NSCLC patients with EGFR mutations: pooled analysis'
(Paz-Ares et al., J Cell Mol Med. 2010; 14: 51-69)." in: Journal of cellular and molecular medicine, Vol. 14, Issue 11, pp. 2693-4, 2010 (PubMed).

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