KCNMA1 antibody (AA 1131-1236)

Catalog No. ABIN672426

Cited in 1 publication. The Rabbit Polyclonal anti-KCNMA1 antibody (ABIN672426) specifically detects KCNMA1 in WB, IHC (p) and IHC (fro). The antibody is reactive with Mouse and Rat samples.

Quick Overview for KCNMA1 antibody (AA 1131-1236) (ABIN672426)

Target: KCNMA1 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, alpha Member 1 (KCNMA1))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNMA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-KCNMA1 Antibody

Binding Specificity: AA 1131-1236

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human BK channel

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-KCNMA1 antibody (ABIN672426)

Sudduth, Weekman, Price, Gooch, Woolums, Norris, Wilcock: "Time-course of glial changes in the hyperhomocysteinemia model of vascular cognitive impairment and dementia (VCID)." in: Neuroscience, Vol. 341, pp. 42-51, (2016) (PubMed).

Target Details for KCNMA1

Target: KCNMA1 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, alpha Member 1 (KCNMA1))

Alternative Name: BK channel

Background:

Synonyms: SLO, BKTM, SLO1, MaxiK, SAKCA, mSLO1, KCa1.1, SLO-ALPHA, bA205K10.1, Calcium-activated potassium channel subunit alpha-1, BK channel, BKCA alpha, Calcium-activated potassium channel, subfamily M subunit alpha-1, K(VCA)alpha, Maxi K channel, Slowpoke homolog, Slo homolog, hSlo, KCNMA1, KCNMA

Background: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).

Gene ID: 3778

UniProt: Q12791

Pathways: Regulation of Hormone Metabolic Process, Sensory Perception of Sound