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Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B) antibody (HRP)
| Antigen | Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B) |
| Synonyms | Darpp32, AU040756, DARPP-32, DARPP32, FLJ20940, Darpp-32, darpp32, darpp-32, PPP1R1B, MGC139723 |
| Clonality | Polyclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Human, Rat (Rattus), Mouse (Murine) |
| Conjugate |
Alternatives HRP |
| Application |
Alternatives Western Blotting (WB), ELISA
|
| Catalog no. | ABIN680332 |
| Quantity | 100 µg (1mg/1ml) |
| Price | 350.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 10 to 15 Business Days |
Additional Information
| Alternative name | DARPP32 |
| Immunogen | Polyclonal antibodies are produced by immunizing animals with synthetic peptide from the human DARPP32 conjugated to KLH |
| Format | Lyophilized |
| Reconstitution | Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%) |
| Isotype | IgG |
| Description | Synonym: DARPP 32, DARPP-32, Dopamine and cAMP regulated neuronal phosphoprotein, Dopamine and cAMP regulated phosphoprotein DARPP 32, Dopamine and cAMP regulated phosphoprotein DARPP32, FLJ20940, IPPD, Neuronal phosphoprotein DARPP 32, PPP1R1B, Protein phosphatase 1 regulatory (inhibitor) subunit 1B, Protein phosphatase 1 regulatory subunit 1B. |
| Molecular Weight | 32kDa |
| Comments |
DARPP32 is expressed in medium sized spiny neurons that also express dopamine D1 receptors. The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation resulting in the phosphorylation of DARPP32 and phosphorylated DARPP32 is a potent protein phosphatase 1. NMDA receptor stimulation elevates intracellular calcium which leads to activation of calcineurin and dephosphorylation of phospho DARPP32 thereby reducing the phosphatase 1 inhibitory activity of DARPP32. |
Application Details
| Application Notes | WB (1:200-1000), ELISA (1:500-1000) |
| Concentration | 1mg/1ml |
| Purification | Antibodies are purified by protein A and peptide affinity chromatography. |
| Buffer | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
| Storage | Ship at room temperature. Store at -20°C |
| Research Area | Signaling |
| Restrictions | For Research Use only |
Alternatives
Alternatives for antigen "Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B)", type "Antibodies"
