IL22 Receptor alpha 1 antibody (AA 41-150)

Catalog No. ABIN748178

Product Details anti-IL22 Receptor alpha 1 Antibody

Target: IL22 Receptor alpha 1 (IL22RA1) (Interleukin 22 Receptor, alpha 1 (IL22RA1))

Binding Specificity: AA 41-150

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL22 Receptor alpha 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Cow,Pig,Horse,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IL-22R

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-IL22 Receptor alpha 1 antibody (ABIN748178)

Zhang, Kolonin: "Cytokine signaling regulating adipose stromal cell trafficking." in: Adipocyte, Vol. 5, Issue 4, pp. 369-374, (2016) (PubMed).

Guo, Wu, Cen, Li, Kong, Zhou: "IL-22-producing Th22 cells play a protective role in CVB3-induced chronic myocarditis and dilated cardiomyopathy by inhibiting myocardial fibrosis." in: Virology journal, Vol. 11, Issue 1, pp. 2511, (2014) (PubMed).

Target Details for IL22 Receptor alpha 1

Target: IL22 Receptor alpha 1 (IL22RA1) (Interleukin 22 Receptor, alpha 1 (IL22RA1))

Alternative Name: IL22RA1 (IL22RA1 Products)

Synonyms: IL22RA1 antibody, CRF2-9 antibody, IL22R antibody, IL22R1 antibody, 9130219A07Rik antibody, ENSMUSG00000073746 antibody, IL-22R antibody, Il22r antibody, RGD1559655 antibody, interleukin 22 receptor subunit alpha 1 antibody, interleukin 22 receptor, alpha 1 antibody, IL22RA1 antibody, Il22ra1 antibody

Background:

Synonyms: IL22R, CRF2-9, IL22R1, Interleukin-22 receptor subunit alpha-1, IL-22 receptor subunit alpha-1, IL-22R-alpha-1, IL-22RA1, Cytokine receptor class-II member 9, Cytokine receptor family 2 member 9, ZcytoR11, IL22RA1

Background: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.

Gene ID: 58985

UniProt: Q8N6P7