DOK1 antibody (pTyr398) (Biotin)

Catalog No. ABIN757659

The Biotin-conjugated Rabbit Polyclonal anti-DOK1 antibody (ABIN757659) specifically detects DOK1 in WB, ELISA, IHC (p) and IHC (fro). The antibody is reactive with Mouse samples.

Quick Overview for DOK1 antibody (pTyr398) (Biotin) (ABIN757659)

Target: DOK1 (Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOK1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-DOK1 Antibody (Biotin)

Binding Specificity: pTyr398

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human DOK1 around the phosphorylation site of Tyr398

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for DOK1

Target: DOK1 (Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1))

Alternative Name: DOK1

Background:

Synonyms: DOK1 phospho Y398, DOK1 phospho Tyr398, p-DOK1 phospho Y398, docking protein 1 downstream of tyrosine kinase 1, Docking protein 1 p62dok Downstream of tyrosine kinase 1 pp62., docking protein 1 62kD downstream of tyrosine kinase 1, Docking protein 1 62kD, Docking protein 1 62kD, Docking protein 1, DOK 1, DOK1, DOK-1, DOK1_HUMAN, Downstream of tyrosine kinase 1, p62dok, P62DOK, pp62, pp62.

Background: Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.

Gene ID: 1796