CDKN2D antibody (AA 65-166) (HRP)

Catalog No. ABIN760715

The Rabbit Polyclonal anti-CDKN2D antibody is suitable to detect CDKN2D in samples from Human. It has been validated for WB, ELISA, IHC (p) and IHC (fro).

Quick Overview for CDKN2D antibody (AA 65-166) (HRP) (ABIN760715)

Target: CDKN2D (Cyclin-Dependent Kinase Inhibitor 2D (p19, Inhibits CDK4) (CDKN2D))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDKN2D antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-CDKN2D Antibody (HRP)

Binding Specificity: AA 65-166

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CDKN2D/p19 INK4d

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CDKN2D

Target: CDKN2D (Cyclin-Dependent Kinase Inhibitor 2D (p19, Inhibits CDK4) (CDKN2D))

Alternative Name: CDKN2D

Background:

Synonyms: CDK inhibitor p19INK4d, CDKN2D, cell cycle inhibitor, Nur77 associating protein, Cyclin dependent kinase inhibitor 2D, Cyclin-dependent kinase 4 inhibitor D, Cyclin-dependent kinase inhibitor 2D p19, inhibits CDK4, inhibitor of cyclin-dependent kinase 4d, INK4D, p19, p19-INK4D, p19INK4d, Similar to cyclin-dependent kinase inhibitor 2D, CDN2D_HUMAN.

Background: The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008].

Gene ID: 1032

Pathways: Cell Division Cycle, Sensory Perception of Sound, Mitotic G1-G1/S Phases, Negative Regulation of intrinsic apoptotic Signaling