COBRA1 antibody

Catalog No. ABIN782439

Product Details anti-COBRA1 Antibody

Target: COBRA1 (Cofactor of BRCA1 (COBRA1))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This COBRA1 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: Specific for the ~62k COBRA1 protein in Western blots of neonatal Rat brain lysate.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse and Rat.

Purification: Protein G Chromatography of Culture Supernatant.

Immunogen: Recombinant full length Human COBRA1 purified from E. coli.

Clone: F7E4

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.05 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody undiluted (in aliquots) at -20 °C.

Target Details for COBRA1

Target: COBRA1 (Cofactor of BRCA1 (COBRA1))

Alternative Name: NELF-B (COBRA1 Products)

Synonyms: LOC100219583 antibody, COBRA1 antibody, NELF-B antibody, bZ1O1.4 antibody, cobra1 antibody, cobra2 antibody, fe01e12 antibody, wu:fe01e12 antibody, zgc:55628 antibody, MGC131073 antibody, Cobra1 antibody, RGD1307832 antibody, A730008L03Rik antibody, AB041607 antibody, AI663983 antibody, Nelf-b antibody, cofactor of BRCA1 antibody, negative elongation factor complex member B antibody, negative elongation factor complex member B L homeolog antibody, LOC100219583 antibody, NELFB antibody, nelfb antibody, nelfb.L antibody, Nelfb antibody

Background: COBRA1 (cofactor of BRCA1) also known as NELF-B, is an essential component of the negative elongation factor (NELF) complex. COBRA1 has been shown to directly bind estrogen receptor alpha (ERα) and repress ERα-mediated transcription (Aiyar SE et al., 2004). COBRA1 has also been demonstrated to interact with c-Jun and c-Fos suggesting a role in modulation of the AP-1 pathway and therefore may be important in cell proliferation, differentiation, apoptosis and oncogeneis (Zhong H et al., 2004).Synonyms: COBRA1, Cofactor of BRCA1, KIAA1182, NELFB, Negative elongation factor B

Gene ID: 25920

NCBI Accession: NP_056271

UniProt: Q8WX92