RAB Guanine Nucleotide Exchange Factor (GEF) 1 (RABGEF1) (Center) antibody

Details for Product No. ABIN783421
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Antigen
Synonyms RABEX5, rabex-5, Rab5ef, Rabex5, Rin2
Epitope
Center
(5), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(20), (9), (9)
Host
Rabbit
(18), (2)
Clonality
Polyclonal
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(19), (9), (3), (2), (2), (2), (2)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN783421
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Immunogen 19 amino acid peptide near the center terminus of human RABEX5
Specificity This antibody detects RABGEF1 at Center. At least four isoforms of RABEX5 are known to exist, this antibody will recognize all four. RABEX5 antibody is predicted to not cross-react with other LRRFIP family members.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse, rat
Purification Affinity chromatography purified via peptide column
Alternative Name RABGEF1
Background RABEX5 is a guanine nucleotide exchange factor (GEF) that forms a complex with rabaptin-5 and specifically activates Rab5, a small GTPase that plays an essential role in endocytic traffic. RABEX-5 is thought to also interact with another member of the Rab family, Rab22, which targets RABEX5 to early endosomes, allowing it to activate Rab5 and thereby promote Rab5-mediated endosome fusion.Synonyms: RABEX5, RAP1, Rab5 GDP/GTP exchange factor, Rabaptin-5-associated exchange factor for Rab5, Rabex-5
Gene ID 27342
NCBI Accession NP_055319
UniProt Q9UJ41
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Background publications Horiuchi, Lippé, McBride et al.: "A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function." in: Cell, Vol. 90, Issue 6, pp. 1149-59, 1997 (PubMed).

Zhu, Liang, Li: "Rabex-5 is a Rab22 effector and mediates a Rab22-Rab5 signaling cascade in endocytosis." in: Molecular biology of the cell, Vol. 20, Issue 22, pp. 4720-9, 2009 (PubMed).

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