RABGEF1 antibody (AA 430-480)

Catalog No. ABIN6991502

Product Details anti-RABGEF1 Antibody

Target: RABGEF1 (RAB Guanine Nucleotide Exchange Factor (GEF) 1 (RABGEF1))

Binding Specificity: AA 430-480

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RABGEF1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: At least four isoforms of RABEX5 are known to exist, this antibody will recognize all four. RABEX5 antibody is predicted to not cross-react with other LRRFIP family members.

Purification: RABEX5 Antibody is affinity chromatography purified via peptide column.

Immunogen: RABEX5 antibody was raised against a 19 amino acid synthetic peptide near the center terminus of human RABEX5. The immunogen is located within amino acids 430 - 480 of RABEX5.

Isotype: IgG

Application Details

Application Notes: RABEX5 antibody can be used for detection of RABEX5 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: RABEX5 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: RABEX5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for RABGEF1

Target: RABGEF1 (RAB Guanine Nucleotide Exchange Factor (GEF) 1 (RABGEF1))

Alternative Name: RABEX5 (RABGEF1 Products)

Synonyms: Rab5ef antibody, Rabex5 antibody, Rin2 antibody, RABEX5 antibody, rabex-5 antibody, rabgef1 antibody, RAB guanine nucleotide exchange factor (GEF) 1 antibody, RAB guanine nucleotide exchange factor 1 antibody, RAB guanine nucleotide exchange factor (GEF) 1 L homeolog antibody, Rabgef1 antibody, RABGEF1 antibody, rabgef1.L antibody

Background: RABEX5 Antibody: RABEX5 is a guanine nucleotide exchange factor (GEF) that forms a complex with rabaptin-5 and specifically activates Rab5, a small GTPase that plays an essential role in endocytic traffic. RABEX-5 is thought to also interact with another member of the Rab family, Rab22, which targets RABEX5 to early endosomes, allowing it to activate Rab5 and thereby promote Rab5-mediated endosome fusion.

Gene ID: 27342

NCBI Accession: NP_055319

UniProt: Q9UJ41

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process