NLRP10 antibody (N-Term)

Catalog No. ABIN783715

This Rabbit Polyclonal antibody specifically detects NLRP10 in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for NLRP10 antibody (N-Term) (ABIN783715)

Target: NLRP10 (NLR Family, Pyrin Domain Containing 10 (NLRP10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP10 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-NLRP10 Antibody

Binding Specificity: N-Term

Specificity: This antibody detects NALP10 at N-term.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide near the amino terminus of human NALP10

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for NLRP10

Target: NLRP10 (NLR Family, Pyrin Domain Containing 10 (NLRP10))

Alternative Name: NLRP10

Background: NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1b, inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1b processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.Synonyms: NACHT LRR and PYD domains-containing protein 10, NALP10, NOD8, Nucleotide-binding oligomerization domain protein 8, PYNOD

Gene ID: 338322

NCBI Accession: NP_789791

UniProt: Q86W26

Pathways: Inflammasome