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Cell Division Cycle 23 Homolog (S. Cerevisiae) (CDC23) (Center) antibody

Details for Product No. ABIN783825, Supplier: Log in to see
Antigen
  • CDC23
  • anaphase-promoting complex subunit 8
  • zgc:56013
  • 6030435O18
  • D18Ertd243e
  • ANAPC8
  • APC8
  • CUT23
Epitope
Center
10
8
4
2
2
2
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
53
28
24
6
4
2
1
1
Host
Rabbit
50
4
Clonality
Polyclonal
Conjugate
Un-conjugated
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
45
32
8
7
6
3
2
2
2
1
Supplier
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Immunogen 17 amino acid peptide near the center of human APC8
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse, rat
Purification Affinity chromatography purified via peptide column
Alternative Name CDC23 / APC8 (CDC23 Antibody Abstract)
Background Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC8 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. In Drosophila, silencing of APC8 results in developmental delay and pupal lethality with elevated levels of apoptosis, high mitotic index, and delayed or blocked mitosis.Synonyms: ANAPC8, Anaphase-promoting complex subunit 8, Cell division cycle protein 23 homolog, Cyclosome subunit 8
Gene ID 8697
NCBI Accession NP_004652
UniProt Q9UJX2
Research Area Coagulation
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Supplier Images
Western Blotting (WB) image for anti-Cell Division Cycle 23 Homolog (S. Cerevisiae) (CDC23) (Center) antibody (ABIN783825) Western blot analysis of APC8 in K562 cell lysate with APC8 antibody at (A) 1 and (B)...
Background publications Pál, Nagy, Ménesi et al.: "Structurally related TPR subunits contribute differently to the function of the anaphase-promoting complex in Drosophila melanogaster." in: Journal of cell science, Vol. 120, Issue Pt 18, pp. 3238-48, 2007 (PubMed).

Peters: "The anaphase promoting complex/cyclosome: a machine designed to destroy." in: Nature reviews. Molecular cell biology, Vol. 7, Issue 9, pp. 644-56, 2006 (PubMed).

Jörgensen, Gräslund, Betz et al.: "Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex." in: Gene, Vol. 262, Issue 1-2, pp. 51-9, 2001 (PubMed).