Cell Division Cycle 23 Homolog (S. Cerevisiae) (CDC23) (Center) antibody

Details for Product No. ABIN783825
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Synonyms CDC23, anaphase-promoting complex subunit 8, zgc:56013, 6030435O18, D18Ertd243e, ANAPC8, APC8, CUT23
(11), (8), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(61), (38), (30), (6), (3), (2), (1), (1)
(59), (3)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(48), (33), (10), (8), (8), (5), (3), (2), (2)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen 17 amino acid peptide near the center of human APC8
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse, rat
Purification Affinity chromatography purified via peptide column
Alternative Name CDC23 / APC8 (CDC23 Antibody Abstract)
Background Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC8 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. In Drosophila, silencing of APC8 results in developmental delay and pupal lethality with elevated levels of apoptosis, high mitotic index, and delayed or blocked mitosis.Synonyms: ANAPC8, Anaphase-promoting complex subunit 8, Cell division cycle protein 23 homolog, Cyclosome subunit 8
Gene ID 8697
NCBI Accession NP_004652
UniProt Q9UJX2
Research Area Coagulation
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Supplier Images
Western Blotting (WB) image for anti-Cell Division Cycle 23 Homolog (S. Cerevisiae) (CDC23) (Center) antibody (ABIN783825) Western blot analysis of APC8 in K562 cell lysate with APC8 antibody at (A) 1 and (B)...
Background publications Pál, Nagy, Ménesi et al.: "Structurally related TPR subunits contribute differently to the function of the anaphase-promoting complex in Drosophila melanogaster." in: Journal of cell science, Vol. 120, Issue Pt 18, pp. 3238-48, 2007 (PubMed).

Peters: "The anaphase promoting complex/cyclosome: a machine designed to destroy." in: Nature reviews. Molecular cell biology, Vol. 7, Issue 9, pp. 644-56, 2006 (PubMed).

Jörgensen, Gräslund, Betz et al.: "Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex." in: Gene, Vol. 262, Issue 1-2, pp. 51-9, 2001 (PubMed).

Catalog No. ABIN783825
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