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Cell Division Cycle 23 Homolog (S. Cerevisiae) (CDC23) (Center) antibody

Details for Product No. ABIN783825
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Antigen
Synonyms CDC23, anaphase-promoting complex subunit 8, zgc:56013, 6030435O18, D18Ertd243e, ANAPC8, APC8, CUT23
Epitope
Center
(8), (8), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(45), (31), (25), (14), (14), (12), (12), (2), (1)
Host
Rabbit
(47), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(36), (20), (10), (9), (8), (3), (2), (2)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN783825
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Immunogen 17 amino acid peptide near the center of human APC8
Purification Affinity chromatography purified via peptide column
Alternative Name CDC23 / APC8
Background Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC8 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle- associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. In Drosophila, silencing of APC8 results in developmental delay and pupal lethality with elevated levels of apoptosis, high mitotic index, and delayed or blocked mitosis.
Alternate names: ANAPC8, Anaphase-promoting complex subunit 8, Cell division cycle protein 23 homolog, Cyclosome subunit 8
Gene ID 8697
NCBI Accession NP_004652
UniProt Q9UJX2
Research Area Coagulation
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C.
Expiry Date 12 months
Background publications Jörgensen, Gräslund, Betz et al.: "Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex." in: Gene, Vol. 262, Issue 1-2, pp. 51-9, 2001 (PubMed).

Peters: "The anaphase promoting complex/cyclosome: a machine designed to destroy." in: Nature reviews. Molecular cell biology, Vol. 7, Issue 9, pp. 644-56, 2006 (PubMed).

Pál, Nagy, Ménesi et al.: "Structurally related TPR subunits contribute differently to the function of the anaphase-promoting complex in Drosophila melanogaster." in: Journal of cell science, Vol. 120, Issue Pt 18, pp. 3238-48, 2007 (PubMed).

Validation Images
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