VEGFD antibody

Catalog No. ABIN783861

The Rabbit Polyclonal anti-VEGFD antibody (ABIN783861) specifically detects VEGFD in WB. The antibody is reactive with Human samples.

Quick Overview for VEGFD antibody (ABIN783861)

Target: VEGFD (Figf) (C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VEGFD antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-VEGFD Antibody

Specificity: This antibody detects VEGF-D / FIGF.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Affinity chromatography

Immunogen: E. coli expressed human VEGF-D

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store at -20 °C. For long term storage, aliquot and store at -70 °C.

Target Details for VEGFD

Target: VEGFD (Figf) (C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf))

Alternative Name: VEGFD

Background: EGF-D is most closely related to VEGF-C by virtue of the presence of N- and C-terminal extensions that are not found in other VEGF family members. In adult human tissues, VEGF-D mRNA is most abundant in heart, lung, skeletal muscle, colon, and small intestine. Analyses of VEGF-D receptor specificity revealed that VEGF-D is a ligand for both VEGF receptors (VEGFRs) VEGFR-2 (Flk1) and VEGFR-3 (Flt4) and can activate these receptors. However, VEGF-D does not bind to VEGFR-1. Expression of a truncated derivative of VEGF-D demonstrated that the receptor-binding capacities reside in the portion of the molecule that is most closely related in primary structure to other VEGF family members and that corresponds to the mature form of VEGF-C. In addition, VEGF-D is a mitogen for endothelial cells. The recombinant VEGF-D as the immunogen was expressed based on sequence from Genebank Accession# D89630, 20-354 aa.Synonyms: FIGF, VEGF-D, Vascular endothelial growth factor D, c-Fos-induced growth factor

Gene ID: 2277

NCBI Accession: NP_004460

UniProt: O43915

Pathways: RTK Signaling