HCRTR1 antibody (Internal Region)

Catalog No. ABIN783920

Product Details anti-HCRTR1 Antibody

Target: HCRTR1 (Hypocretin (Orexin) Receptor 1 (HCRTR1))

Binding Specificity: Internal Region

Reactivity: Human, Rat, Mouse, Dog, Sheep

Host: Goat

Clonality: Polyclonal

Conjugate: This HCRTR1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: C-RNWKRPSDQL GD

Specificity: This antibody detects Orexin receptor 1.

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat and Canine (Dog), Sheep.
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_001516.1. Genename: HCRTR1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for HCRTR1

Target: HCRTR1 (Hypocretin (Orexin) Receptor 1 (HCRTR1))

Alternative Name: Orexin Receptor Type 1 (HCRTR1 Products)

Synonyms: OX1R antibody, Ox1r antibody, Hctr1 antibody, HCRTR1 antibody, hypocretin receptor 1 antibody, hypocretin (orexin) receptor 1 antibody, HCRTR1 antibody, Hcrtr1 antibody

Background: Orexins are endogeneous peptides that activate Orexin Receptor type 1 and type 2, two closely related G-protein coupled receptors. Orexins-A and -B are hypothalamic peptides derived from a precursor called preproorexin and affect the stimulation of food intake. They act on G protein receptors named orexin receptor-1 (OX1R) and orexin receptor-2 (OX2R), respectively.timulation of these receptors by orexins causes an increase in intracellular calcium levels in hypothalamic cells in vitro. In vivo, orexins control feeding and may also be involved in modulating sleep-wake cycles and other hypothalamic functions.Synonyms: HCRTR1, Hypocretin receptor type 1, Ox1r

Gene ID: 3061

NCBI Accession: NP_001516

Pathways: Feeding Behaviour