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HCRTR1 antibody (Internal Region)
HCRTR1
Reactivity: Human, Rat, Mouse, Dog, Sheep
WB, EIA
Host: Goat
Polyclonal
unconjugated
Product Details anti-HCRTR1 Antibody
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Target
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HCRTR1
(Hypocretin (Orexin) Receptor 1 (HCRTR1))
Binding Specificity
All epitopes for HCRTR1 antibodies
Internal Region
Reactivity
All reactivities for HCRTR1 antibodies
Human, Rat, Mouse, Dog, Sheep
Host
All hosts for HCRTR1 antibodies
Goat
Clonality
All clonalities for HCRTR1 antibodies
Polyclonal
Conjugate
All conjugates for HCRTR1 antibodies
This HCRTR1 antibody is un-conjugated
Application
All applications for HCRTR1 antibodies
Western Blotting (WB), Enzyme Immunoassay (EIA)
Sequence
C-RNWKRPSDQL GD
Specificity
This antibody detects Orexin receptor 1.
Cross-Reactivity (Details)
Species reactivity (expected):Mouse, Rat and Canine (Dog), Sheep. Species reactivity (tested):Human.
Purification
Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
Immunogen
Peptide with sequence from the internal region of the protein sequence according to NP_001516.1. Genename: HCRTR1
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for HCRTR1
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Target
HCRTR1
(Hypocretin (Orexin) Receptor 1 (HCRTR1))
Alternative Name
Orexin Receptor Type 1 (HCRTR1 Products )
Synonyms
OX1R antibody, Ox1r antibody, Hctr1 antibody, HCRTR1 antibody, hypocretin receptor 1 antibody, hypocretin (orexin) receptor 1 antibody, HCRTR1 antibody, Hcrtr1 antibody
Background
Orexins are endogeneous peptides that activate Orexin Receptor type 1 and type 2, two closely related G-protein coupled receptors. Orexins-A and -B are hypothalamic peptides derived from a precursor called preproorexin and affect the stimulation of food intake. They act on G protein receptors named orexin receptor-1 (OX1R) and orexin receptor-2 (OX2R), respectively.timulation of these receptors by orexins causes an increase in intracellular calcium levels in hypothalamic cells in vitro. In vivo, orexins control feeding and may also be involved in modulating sleep-wake cycles and other hypothalamic functions.Synonyms: HCRTR1, Hypocretin receptor type 1, Ox1r
Gene ID
3061
NCBI Accession
NP_001516
Pathways
Feeding Behaviour
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