TGFBR1 antibody (Internal Region)

Catalog No. ABIN784282

This Goat Polyclonal antibody specifically detects TGFBR1 in WB and EIA. It exhibits reactivity toward Human, Mouse, Rat, Cow, Pig and Dog.

Quick Overview for TGFBR1 antibody (Internal Region) (ABIN784282)

Target: TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))

Reactivity: Human, Mouse, Rat, Cow, Pig, Dog

Host: Goat

Clonality: Polyclonal

Conjugate: This TGFBR1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-TGFBR1 Antibody

Binding Specificity: AA 50-63, Internal Region

Sequence: TDGLCFVSVT ETTD

Specificity: This antibody is expected to recognize both reported isoforms (NP_004603.1, NP_001124388.1). The immunizing peptide represents part of a potential extracellular domain.

Cross-Reactivity (Details): Species reactivity (expected):Human, Canine (Dog), Pig, Cow.
Species reactivity (tested):Mouse, Rat.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_004603.1, NP_001124388.1. Genename: TGFBR1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for TGFBR1

Target: TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))

Alternative Name: TGFBR1 / ALK-5

Background: Three members of the TGF beta family, TGF beta 1, TGF beta 2 and TGF beta 3, are known in mammals. TGF betas mediate their activity by high affinity binding to the type 2 receptor, which requires both its kinase activity and association with members of a series of related type 1 receptors called activin receptor like kinase (ALK) 1 to 6. Of these, only ALK5 has been shown to represent a functional TGF beta type 1 receptor, but only ALK2 and ALK4 bind activin with high affinity. TGF beta R3 binds TGF beta and retains TGF beta for presentation to the signaling receptors.Synonyms: ALK5, Activin receptor-like kinase 5, SKR4, Serine/threonine-protein kinase receptor R4, TGF-beta receptor type-1, TGF-beta type I receptor, TGFR-1, TbetaR-I, Transforming growth factor-beta receptor type I

Gene ID: 7046

NCBI Accession: NP_001124388

Pathways: Growth Factor Binding