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Details for Product No. ABIN807923

Notch 1 (NOTCH1) antibody

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Antigen
Synonyms hN1, TAN1, 9930111A19Rik, Mis6, N1, Tan1, lin-12, NOTCH, Xotch, notch, notch-1, notch1-a, xnotch, xnotch1, notch1, NOTCH1, hn1, tan1, xotch
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
Pubmed 7 references available
Catalog no. ABIN807923
Quantity 0.1 mg
Price
290.40 $   Plus shipping costs $45.00
Shipping to
Availability Please inquire for availability
Immunogen GST fusion protein containing cdc10-NCR region of mouse Notch1
Clone MN1A
Isotype IgG1
Specificity The mouse monoclonal antibody mN1A recognizes intracellular domain of Notch 1 protein, mainly its activated form. The unprocessed Notch 1 protein is recognized with lower affinity.
Purification Purified from cell culture supernatant by protein-A affinity chromatography.
Alternative Name NOTCH1
Gene ID 4851
Comment

Transcription Regulation & Nuclear Proteins (Rodent), Transcription Regulation & Nuclear Proteins (Human)
Negative Species: Rat

Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Storage 4 °C
Huppert, Le, Schroeter et al.: "Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1." in: Nature, Vol. 405, Issue 6789, pp. 966-70, 2000 (PubMed).

Espinosa, Santos, Inglés-Esteve et al.: "p65-NFkappaB synergizes with Notch to activate transcription by triggering cytoplasmic translocation of the nuclear receptor corepressor N-CoR." in: Journal of cell science, Vol. 115, Issue Pt 6, pp. 1295-303, 2002 (PubMed). Further details: �

Sun, Li, Vercherat et al.: "Stra13 regulates satellite cell activation by antagonizing Notch signaling." in: The Journal of cell biology, Vol. 177, Issue 4, pp. 647-57, 2007 (PubMed).

Tagami, Okochi, Yanagida et al.: "Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1." in: Molecular and cellular biology, Vol. 28, Issue 1, pp. 165-76, 2007 (PubMed).

Watanabe, Nagaoka, Lee et al.: "Enhancement of Notch receptor maturation and signaling sensitivity by Cripto-1." in: The Journal of cell biology, Vol. 187, Issue 3, pp. 343-53, 2009 (PubMed).

Kefas, Comeau, Floyd et al.: "The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 48, pp. 15161-8, 2009 (PubMed).

Khwaja, Liu, Tong et al.: "HIV-1 Rev-binding protein accelerates cellular uptake of iron to drive Notch-induced T cell leukemogenesis in mice." in: The Journal of clinical investigation, Vol. 120, Issue 7, pp. 2537-48, 2010 (PubMed).

Alternatives for antigen "Notch 1 (NOTCH1)", type "Antibodies"
Hosts (85), (61), (5), (5), (3), (2)
Reactivities (119), (75), (29), (4), (2), (1), (1), (1), (1), (1)
Applications (90), (52), (41), (40), (27), (11), (9), (9), (5), (4), (2), (2), (2)
Conjugates (9), (7), (2), (1), (1), (1), (1), (1)
Epitopes (12), (9), (6), (5), (5), (5), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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