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Endoglin (ENG) antibody (Biotin)

Antigen

Endoglin (ENG)
Synonyms END, ORW, HHT1, ORW1, CD105, FLJ41744, AI528660, AI662476, S-endoglin, Eng, MGC124909, ENG, MGC137842, DKFZp469D0419
Clonality Monoclonal (MEM-229)
Host
Alternatives

Mouse
Reactivity
Alternatives

Human, Pig (Porcine)
Conjugate
Alternatives Biotin
Application
Alternatives Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
5 references available
Catalog no. ABIN810077
Quantity 0.1 mg
Price 363.00 $   Plus shipping costs $45.00
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Additional Information
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Alternative name CD105
Gene ID 2022
Immunogen Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA.
Isotype IgG2a
Clone MEM-229
Description CD Antigens & MHC (Veterinary), CD and Related Antigens (Human)
Specificity The antibody MEM-229 recognizes CD105 (Endoglin), a 180 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow, it is also present on syncytiotrophoblast on placenta throughout pregnancy.

Application Details
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Purification Purified from ascites by protein-A affinity chromatography.
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Storage Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Research Area Stem Cells, CD Antigens, Surface Receptors of Immune Cells
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Product Li, Issa, Kumar et al.: "CD105 prevents apoptosis in hypoxic endothelial cells." in: Journal of cell science, Vol. 116, Issue Pt 13, pp. 2677-85, 2003 (PubMed).

Zhu, Sun, Xie et al.: "Hypoxic induction of endoglin via mitogen-activated protein kinases in mouse brain microvascular endothelial cells." in: Stroke; a journal of cerebral circulation, Vol. 34, Issue 10, pp. 2483-8, 2003 (PubMed).

Guo, Slevin, Li et al.: "CD105 inhibits transforming growth factor-beta-Smad3 signalling." in: Anticancer research, Vol. 24, Issue 3a, pp. 1337-45, 2004 (PubMed).

Warrington, Hillarby, Li et al.: "Functional role of CD105 in TGF-beta1 signalling in murine and human endothelial cells." in: Anticancer research, Vol. 25, Issue 3B, pp. 1851-64, 2005 (PubMed).

Piao, Tokunaga: "Significant expression of endoglin (CD105), TGFbeta-1 and TGFbeta R-2 in the atherosclerotic aorta: an immunohistological study." in: Journal of atherosclerosis and thrombosis, Vol. 13, Issue 2, pp. 82-9, 2006 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Endoglin (ENG)", type "Antibodies"
Hosts Mouse (110), Rabbit (78), Rat (23), Chicken (2), Goat (2)
Reactivities Human (146), Mouse (Murine) (49), Pig (Porcine) (29), Dog (Canine) (23), Rat (Rattus) (17), Horse (Equine) (9), Cow (Bovine) (7), Chicken (6), Cat (Feline) (1)
Applications Flow Cytometry (FACS) (127), Western Blotting (WB) (107), Immunohistochemistry (IHC) (49), ELISA (46), Immunoprecipitation (IP) (42), Immunofluorescence (IF) (34), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (28), Immunohistochemistry (Fixed) (IHC (fx)) (19), Immunocytochemistry (ICC) (8), Immunohistochemistry (Frozen Sections) (IHC (fro)) (7), Functional Studies (Func) (6), Immunoassay (IA) (6), Cellular Assay (CA) (4), Immunostaining (ISt) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Blocking Antibody (Inhibition) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates PE (24), FITC (19), Biotin (15), APC (9), Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), PE,Cy5.5 (3), DyLight 649 (2), RPE (2), CF (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), DY647 (1), Dyomics 647 (1), Gold (1), HRP (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes AA 26-176 (5), Extracellular Domain (4), N-Term (3), C-Term (2), Center (2), Soluble (2), AA 341-470 (1), Center,Glu395 (1), Internal Region (1), Pro430 (1)