PDE10A antibody

Catalog No. ABIN2728473

The Mouse Monoclonal anti-PDE10A antibody is suitable to detect PDE10A in samples from Human. It has been validated for WB and FACS.

Quick Overview for PDE10A antibody (ABIN2728473)

Target: PDE10A (phosphodiesterase 10A (PDE10A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PDE10A antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: 4A10

Product Details anti-PDE10A Antibody

Characteristics: Homo sapiens phosphodiesterase 10A (PDE10A), transcript variant 2

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human PDE10A (NP_006652) produced in HEK293T cell.

Isotype: IgG1

Application Details

Application Notes: WB:1:500, FC:1:50

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS ( pH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for PDE10A

Target: PDE10A (phosphodiesterase 10A (PDE10A))

Alternative Name: PDE10A

Background: Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3'cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11, PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously,with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility,platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.

Molecular Weight: 88.4 kDa

Gene ID: 10846

NCBI Accession: NM_006661

HGNC: 10846

Pathways: cAMP Metabolic Process