TDP1 antibody

Catalog No. ABIN2733391

The Mouse Monoclonal anti-TDP1 antibody (Clone 4H1) (ABIN2733391) specifically detects TDP1 in WB. The antibody is reactive with Human samples.

Quick Overview for TDP1 antibody (ABIN2733391)

Target: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TDP1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 4H1

Product Details anti-TDP1 Antibody

Characteristics: Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human TDP1(NP_060789) produced in HEK293T cell.

Isotype: IgG1

Application Details

Application Notes: WB 1:2000,

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for TDP1

Target: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Alternative Name: TDP1

Background: The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

Molecular Weight: 68.2 kDa

Gene ID: 55775

NCBI Accession: NM_018319

HGNC: 55775