TAB2 antibody

Catalog No. ABIN865507

This Mouse Monoclonal antibody specifically detects TAB2 in WB, ELISA and FACS. It exhibits reactivity toward Human and Rat.

Quick Overview for TAB2 antibody (ABIN865507)

Target: TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This TAB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: 3B5

Product Details anti-TAB2 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human TAB2 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: WB: 1/500 - 1/2000, FC: 1/200-1/400, ELISA: Propose dilution 1/10000.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100g/100l

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for TAB2

Target: TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))

Alternative Name: TAB2

Background: The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Synonyms: CHTD2, FLJ21885, KIAA0733, MAP3K7IP2, TAB2

Molecular Weight: 80kDa

Gene ID: 23118

Pathways: TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway