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CHEK2 antibody (AA 514-518)

The Rabbit Polyclonal anti-CHEK2 antibody is suitable to detect CHEK2 in samples from Human. It has been validated for WB.

Catalog No. ABIN871442

$240.90

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Quick Overview for CHEK2 antibody (AA 514-518) (ABIN871442)

Target

See all CHEK2 Antibodies

CHEK2 (Checkpoint Kinase 2 (CHEK2))

Reactivity

Human

Host

Rabbit

Clonality

Polyclonal

Conjugate

This CHEK2 antibody is un-conjugated

Application

Western Blotting (WB)

Discover our top product CHEK2 Primary Antibody

Binding Specificity
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AA 514-518

Specificity

The antibody detects endogenous levels of total Chk2 protein.

Purification

Affinity purified

Immunogen

Peptide sequence around AA 514-518 (Q-P-S-T-S) derived from Chk2 Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
anti-Checkpoint Kinase 2 (CHEK2) (pThr387) antibody
CHEK2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibody
CHEK2 Reactivity: Human WB, ELISA, IF, IHC (p) Host: Mouse Monoclonal 4B7 unconjugated

anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibody
CHEK2 Reactivity: Human WB, IP Host: Rabbit Polyclonal unconjugated

anti-Checkpoint Kinase 2 (CHEK2) (pThr383) antibody
CHEK2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-Checkpoint Kinase 2 (CHEK2) (pSer516) antibody
CHEK2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-Checkpoint Kinase 2 (CHEK2) (pThr68) antibody
CHEK2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-Checkpoint Kinase 2 (CHEK2) antibody
CHEK2 Reactivity: Human, Monkey, Dog WB, IHC, IF, IHC (p), FACS Host: Mouse Monoclonal 10G7 unconjugated

anti-Checkpoint Kinase 2 (CHEK2) antibody
CHEK2 Reactivity: Human, Dog WB, IHC, IF, IHC (p), IP, FACS Host: Mouse Monoclonal 5C4 unconjugated

anti-Checkpoint Kinase 2 (CHEK2) antibody
CHEK2 Reactivity: Human, Dog WB, IHC, IHC (p), IP, FACS Host: Mouse Monoclonal 2H5 unconjugated

anti-Checkpoint Kinase 2 (CHEK2) antibody
KD Validated CHEK2 Reactivity: Human WB, IF (p), FACS Host: Rabbit Monoclonal 23GB3460 unconjugated Recombinant Antibody

Application Notes

Western blotting: 1:500-1:1000

Restrictions

For Research Use only
Format

Liquid

Concentration

1 mg/mL

Buffer

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative

Sodium azide

Precaution of Use

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

4 °C/-20 °C

Storage Comment

Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Target

CHEK2 (Checkpoint Kinase 2 (CHEK2))

Alternative Name

Chk2

Background

The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation

Molecular Weight

62 kDa

Gene ID

11200

NCBI Accession

NP_001005

UniProt

O96017

Pathways

p53 Signaling, Apoptosis, Cell Division Cycle