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MAPT antibody (Microtubule-Associated Protein tau) (AA 725-729)

Details for Product anti-MAPT Antibody No. ABIN871527, Supplier: Log in to see
Antigen
Alternatives
anti-Human MAPT antibody for Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections)
Epitope
AA 725-729
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
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Host
Rabbit
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Clonality
Polyclonal
Conjugate
This MAPT antibody is un-conjugated
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Application
Western Blotting (WB)
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Supplier
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Immunogen Peptide sequence around AA 725-729 (T-G-S-I-D) derived from Rat Tau Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Specificity The antibody detects endogenous level of total Tau protein.
Purification Affinity purified
Alternative Name Tau (MAPT Antibody Abstract)
Background Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Molecular Weight 78 kDa
Gene ID 2947
NCBI Accession NP_058908
UniProt P19332
Research Area Neurology, Cytoskeleton, Alzheimer's Disease
Pathways MAPK Signaling, Microtubule Dynamics
Application Notes Western blotting: 1:500-1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Watt, Sever: "Non-profit publishing: open access and the end of copyright transfer." in: Journal of cell science, Vol. 117, Issue Pt 1, pp. 1, 2003 (PubMed).

Hanger, Betts, Loviny et al.: "New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry." in: Journal of neurochemistry, Vol. 71, Issue 6, pp. 2465-76, 1998 (PubMed).

Bramblett, Goedert, Jakes et al.: "Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding." in: Neuron, Vol. 10, Issue 6, pp. 1089-99, 1993 (PubMed).