GABRA3 antibody (AA 33-37)

Catalog No. ABIN871662

Product Details anti-GABRA3 Antibody

Target: GABRA3 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3))

Binding Specificity: AA 33-37

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABRA3 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: The antibody detects endogenous level of total GABA A Receptor a3 protein.

Purification: Affinity purified

Immunogen: Peptide sequence around AA 33-37 (R-R-Q-E-P) derived from Rat GABA A Receptor a3. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Application Details

Application Notes: Western blotting: 1:500-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for GABRA3

Target: GABRA3 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3))

Abstract: GABRA3 Products

Synonyms: GABRA3 antibody, Gabra-3 antibody, si:ch211-113k9.1 antibody, gamma-aminobutyric acid type A receptor alpha3 subunit antibody, gamma-aminobutyric acid (GABA) A receptor, alpha 3 antibody, gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3 antibody, gamma-aminobutyric acid receptor subunit alpha-3 antibody, GABRA3 antibody, gabra3 antibody, Gabra3 antibody, LOC100653496 antibody

Background: GABA (g-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission (1). Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site (2). Two isoforms of GABA(B)R1 have been cloned: GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a 95 kD protein (3). G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition, GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation

Molecular Weight: 51 kDa

Gene ID: 24947

NCBI Accession: NP_058765

UniProt: P20236