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Adiponectin (ADIPOQ) (AA 235-239) antibody

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Antigen
Epitope
AA 235-239
54
49
28
13
13
11
10
10
7
6
6
6
5
5
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
474
162
113
30
15
4
4
3
1
1
Host
Rabbit
376
230
16
11
4
3
Clonality
Polyclonal
Conjugate
Un-conjugated
70
28
24
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
419
369
108
70
45
35
34
30
30
14
12
9
8
2
2
2
2
1
1
1
1
1
1
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Immunogen Peptide sequence around AA 235-239 (T-G-F-L-L) derived from Human Adiponectin. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Specificity The antibody detects endogenous level of total Adiponectin protein.
Purification Affinity purified
Alternative Name Adiponectin
Background Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-a by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex,
Molecular Weight 27 kDa
Gene ID 9370
NCBI Accession NP_001171
UniProt Q15848
Research Area Cancer, Atherosclerosis, Metabolism, Hormones
Application Notes Western blotting: 1:500-1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Richards, Stephens, Charlton, Jones, Macdonald, Prins, Whitehead: "Adiponectin multimerization is dependent on conserved lysines in the collagenous domain: evidence for regulation of multimerization by alterations in posttranslational modifications." in: Molecular endocrinology (Baltimore, Md.), Vol. 20, Issue 7, pp. 1673-87, 2006 (PubMed).

Yamauchi, Kamon, Waki, Terauchi, Kubota, Hara, Mori, Ide, Murakami, Tsuboyama-Kasaoka, Ezaki, Akanuma, Gavrilova, Vinson, Reitman, Kagechika, Shudo, Yoda, Nakano, Tobe, Nagai, Kimura, Tomita, Froguel et al.: "The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. ..." in: Nature medicine, Vol. 7, Issue 8, pp. 941-6, 2001 (PubMed).