TNFRSF10B antibody

Catalog No. ABIN920744

Product Details anti-TNFRSF10B Antibody

Target: TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNFRSF10B antibody is un-conjugated

Application: Flow Cytometry (FACS)

Specificity: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including Tumor Necrosis Factor (TNF) and Fas Ligand in the TNF family through their death domain containing receptors, TNF Receptor 1 (TNFR1) and Fas, respectively. Another member in the TNF family has been identified and designated TRAIL (TNF Related Apoptosis Inducing Ligand) and Apo2L (Apo2 Ligand). Receptors for TRAIL include two death domain containing receptors, DR4 and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. DcR1 (TRID), like the related death receptors DR4 and DR5, contains two extracellular cysteine rich domains. However, DcR1 contains no intra- cellular death domain and is thus incapable of signaling apoptosis. It has been suggested that DcR1 is responsible for TRAIL resistance in normal human tissues including heart, placenta, lung, liver, kidney, spleen, and bone marrow. DR5 is a member of the TNF receptor superfamily, and contains an intracellular death domain. This receptor can be activated by Tumor Necrosis Factor related apoptosis including ligand (TNFSF10/TRAIL/APO2L), and tranduces apoptosis signal. Studies with FADD deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.

Characteristics: Cellular Localization: This antibody recognizes the extracellular domain of DR5Ig

Purification: Purified from hybridoma culture supernatant

Immunogen: Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5.

Clone: DR5-01

Isotype: IgG1

Application Details

Restrictions: For Research Use only

Handling

Buffer: 100 µg of monoclonal antibody at approxiamtely 1 mg/mL in PBS containing 15 mM sodium azide, pH 7.4.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for TNFRSF10B

Target: TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

Alternative Name: DR5 (TNFRSF10B Products)

Pathways: p53 Signaling, Apoptosis, Positive Regulation of Endopeptidase Activity