IDE antibody (N-Term)

Catalog No. ABIN927297

The Rabbit Polyclonal anti-IDE antibody (ABIN927297) specifically detects IDE in WB. The antibody is reactive with Human samples.

Quick Overview for IDE antibody (N-Term) (ABIN927297)

Target: IDE (Insulin-Degrading Enzyme (IDE))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IDE antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IDE Antibody

Binding Specificity: N-Term

Purification: Purified

Immunogen: IDE antibody was raised in rabbit using the N terminal of IDE as the immunogen

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Comment:

IDE Blocking Peptide, (ABIN936344), is also available for use as a blocking control in assays to test for specificity of this IDE antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for IDE

Target: IDE (Insulin-Degrading Enzyme (IDE))

Alternative Name: IDE

Background: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Synonyms: Polyclonal IDE antibody, Anti-IDE antibody, insulin-degrading enzyme antibody, FLJ35968 antibody, INSULYSIN antibody.

Pathways: SARS-CoV-2 Protein Interactome