APP antibody (C-Term)

Catalog No. ABIN927396

The Rabbit Polyclonal anti-APP antibody (ABIN927396) specifically detects APP in WB. The antibody is reactive with Human and Mouse samples.

Quick Overview for APP antibody (C-Term) (ABIN927396)

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-APP Antibody

Binding Specificity: C-Term

Cross-Reactivity: Mouse (Murine)

Purification: Purified

Immunogen: App antibody was raised in rabbit using the C terminal of App as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

App Blocking Peptide, (ABIN938182), is also available for use as a blocking control in assays to test for specificity of this App antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for APP

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Alternative Name: App

Background: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a  number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of  patients with Alzheimer disease. Synonyms: Polyclonal App antibody, Anti-App antibody, amyloid beta, A4 precursor protein antibody, Ag antibody, Abpp antibody, Adap antibody, Cvap antibody, Abeta antibody, betaApp antibody, AL024401 antibody, E030013M08Rik antibody, App antibody.

Pathways: Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour