Mre11 antibody (Middle Region)

Catalog No. ABIN928874

The Rabbit Polyclonal anti-Mre11 antibody is suitable to detect Mre11 in samples from Human. It has been validated for WB.

Quick Overview for Mre11 antibody (Middle Region) (ABIN928874)

Target: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Mre11 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Mre11 Antibody

Binding Specificity: Middle Region

Purification: Purified

Immunogen: MRE11 A antibody was raised in rabbit using the middle region of MRE11 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

MRE11A Blocking Peptide, (ABIN5614834), is also available for use as a blocking control in assays to test for specificity of this MRE11A antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for Mre11

Target: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Alternative Name: MRE11A

Background: This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog, this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. Synonyms: Polyclonal MRE11A antibody, Anti-MRE11A antibody, MRE11 meiotic recombination 11 homolog A, S. cerevisiae antibody, ATLD antibody, HNGS1 antibody, MRE11 antibody, MRE11B antibody.

Pathways: DNA Damage Repair