CASP5 antibody (Middle Region)

Catalog No. ABIN929108

The Rabbit Polyclonal anti-CASP5 antibody is suitable to detect CASP5 in samples from Human. It has been validated for WB.

Quick Overview for CASP5 antibody (Middle Region) (ABIN929108)

Target: CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CASP5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CASP5 Antibody

Binding Specificity: Middle Region

Purification: Purified

Immunogen: CASP5 antibody was raised in rabbit using the middle region of CASP5 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

CASP5 Blocking Peptide, (ABIN5612633), is also available for use as a blocking control in assays to test for specificity of this CASP5 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for CASP5

Target: CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))

Alternative Name: CASP5

Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein, this process requires Fas-mediated dephosphorylation of Max. Synonyms: Polyclonal CASP5 antibody, Anti-CASP5 antibody, caspase 5, apoptosis-related cysteine peptidase antibody, ICE(rel)III antibody, ICEREL-III antibody, ICH-3 antibody, MGC141966 antibody.

Pathways: Inflammasome