CD36 Molecule (thrombospondin Receptor) (CD36) antibody

Antigen: CD36 Molecule (thrombospondin Receptor) (CD36)

Synonyms: FAT, GP4, GP3B, GPIV, CHDS7, PASIV, SCARB3

Clonality: Monoclonal (TR9)

Host: Mouse

Reactivity: Human

Application: Flow Cytometry (FACS)

Catalog no.: ABIN94082

Additional Information

Alternative name: CD36

Immunogen: Platelets

Format: Purified

Isotype: IgG1  (Matching secondary antibodies)

Clone: TR9

Description: CD36 (fatty acid translocase, FAT) is an 88 kDa ditopic glycosylated protein that belongs tothe class B family of scavenger receptors. CD36 is expressed by most resting marginal zoneB cells but not by follicular and B1 B cells, and it is rapidly induced on Follicular B cells invitro upon TLR and CD40 stimulation. CD36 does not affect the development of B cells, butmodulates both primary and secondary antibody response. Similarly to glucose transporterGLUT4, CD36 is translocated from intracellular pools to the plasma membrane following cellstimulation by insulin. In mouse, CD36 is responsible for gustatory perception of long-chainfatty acids.

Specificity: The antibody TR9 reacts with CD36 (GPIIIb), a 85 kDa integral membrane glycoproteinexpressed on platelets, macrophages, endothelial cells, early erythroid cells andmegakaryocytes. The antibody TR9 cross-blocks binding of FITC-labeled standard antibodyOKM5.Anti-CD36 antibodies inhibit adhesive functions (e.g. adherence of infected erythrocytes totarget cells).

Application Details

Concentration: 1 mg/ml

Purity: > 95% (by SDS-PAGE)

Purification: Purified from ascites by precipitation methods and ion exchange chromatography.

Buffer: 20 mM Tris/HCl with 15 mM sodium azide, approx. pH 7.4

Storage: Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles.

Research Area: Cancer, Atherosclerosis, Hematopoietic Progenitors, Hematopoietic Stem Cells, CD Antigens, Surface Receptors of Immune Cells

Restrictions: For Research Use only

Images

Surface staining of human platelets with anti-CD36 (TR9) FITC.