AF4/FMR2 Family, Member 4 (AFF4) (N-Term), (AA 1-30), (N-Term) antibody

Details for Product No. ABIN950293
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Antigen
Synonyms AF5Q31, MCEF, Alf4, Laf4l, AFF4, RA_m002_jsmFBA6Br
Epitope
N-Term, AA 1-30, N-Term
(3), (2), (2), (2), (1), (1)
Reactivity
Human
(26), (16), (15), (11), (11), (11)
Host
Rabbit
(22), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(15), (9), (8), (3), (2), (1)
Pubmed 6 references available
Catalog no. ABIN950293
Quantity 0.4 mL
Price
357.50 $   Plus shipping costs $45.00
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Immunogen KLH conjugated synthetic peptide between 1~30 amino acids from the N-terminal region of human AF5q31
Specificity This antibody reacts to AFF4.
Purification Affinity chromatography on Protein A
Alternative Name AFF4 / MCEF
Background Alternate names: AF4/FMR2 family member 4, AF5Q31, ALL1-fused gene from chromosome 5q31, HSPC092, Major CDK9 elongation factor-associated protein
Gene ID 27125
NCBI Accession NP_055238
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) sodium azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Estable, Naghavi, Kato et al.: "MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein." in: Journal of biomedical science, Vol. 9, Issue 3, pp. 234-45, 2002 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Sugiyama, Masuda, Shinoda et al.: "Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 6, pp. 1103-9, 2007 (PubMed).

Niedzielski, Hopewell, Ismail et al.: "MCEF is localized to the nucleus by protein sequences encoded within three distinct exons, where it represses HIV-1 Tat-transactivation of LTR-directed transcription." in: International journal of biological sciences, Vol. 3, Issue 4, pp. 225-36, 2007 (PubMed).

Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

Lin, Smith, Takahashi et al.: "AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia." in: Molecular cell, Vol. 37, Issue 3, pp. 429-37, 2010 (PubMed).

Hosts (22), (5)
Reactivities (26), (16), (15), (11), (11), (11)
Applications (15), (9), (8), (3), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (2), (2), (2), (1), (1)
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