anti-AFF4 antibody (AF4/FMR2 Family, Member 4) (N-Term)

Details for Product anti-AFF4 Antibody No. ABIN950293
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Antigen
Synonyms AFF4, RA_m002_jsmFBA6Br, AF5Q31, MCEF, Alf4, Laf4l
Epitope
N-Term, AA 1-30
(16), (16), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(52), (19), (17)
Host
Rabbit
(45), (8)
Clonality
Polyclonal
Conjugate
This AFF4 antibody is un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(38), (21), (10), (4), (4), (3), (2), (2), (1)
Pubmed 6 references available
Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Immunogen KLH conjugated synthetic peptide between 1~30 amino acids from the N-terminal region of human AF5q31
Isotype Ig
Specificity This antibody reacts to AFF4.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name AFF4 / MCEF (AFF4 Antibody Abstract)
Background Synonyms: AF4/FMR2 family member 4, AF5Q31, ALL1-fused gene from chromosome 5q31, HSPC092, Major CDK9 elongation factor-associated protein
Gene ID 27125
NCBI Accession NP_055238
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Lin, Smith, Takahashi et al.: "AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia." in: Molecular cell, Vol. 37, Issue 3, pp. 429-37, 2010 (PubMed).

Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

Niedzielski, Hopewell, Ismail et al.: "MCEF is localized to the nucleus by protein sequences encoded within three distinct exons, where it represses HIV-1 Tat-transactivation of LTR-directed transcription." in: International journal of biological sciences, Vol. 3, Issue 4, pp. 225-36, 2007 (PubMed).

Sugiyama, Masuda, Shinoda et al.: "Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 6, pp. 1103-9, 2007 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Estable, Naghavi, Kato et al.: "MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein." in: Journal of biomedical science, Vol. 9, Issue 3, pp. 234-45, 2002 (PubMed).

Validation Images
Catalog No. ABIN950293
357.50 $
Plus shipping costs $45.00
Quantity
Price
0.4 mL
357.50 $

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