ACTN2 antibody (C-Term)

Catalog No. ABIN950370

This anti-ACTN2 antibody is a Rabbit Polyclonal antibody detecting ACTN2 in WB and EIA. Suitable for Human and Mouse.

Quick Overview for ACTN2 antibody (C-Term) (ABIN950370)

Target: ACTN2 (Actinin, alpha 2 (ACTN2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACTN2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-ACTN2 Antibody

Binding Specificity: AA 750-779, C-Term

Specificity: This antibody reacts to Alpha-actinin-2.

Cross-Reactivity (Details): Species reactivity (tested):Mouse.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 750-779 amino acids from the C-terminal region of human ACTN2

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ACTN2

Target: ACTN2 (Actinin, alpha 2 (ACTN2))

Alternative Name: alpha-Actinin-2 / ACTN2

Background: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles.Synonyms: Alpha actinin skeletal muscle isoform 2, F-actin cross-linking protein

Gene ID: 88

NCBI Accession: NP_001094

Pathways: Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity