CRYGS antibody (C-Term)

Catalog No. ABIN950652

Product Details anti-CRYGS Antibody

Target: CRYGS (Crystallin, gamma S (CRYGS))

Binding Specificity: AA 136-166, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRYGS antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to human and mouse CRYGS.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 136-166 amino acids from the C-terminal region of human CRYGS

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CRYGS

Target: CRYGS (Crystallin, gamma S (CRYGS))

Alternative Name: beta-Crystallin S (CRYGS Products)

Synonyms: AI327013 antibody, Opj antibody, rncat antibody, CRYG8 antibody, CTRCT20 antibody, crystallin, gamma S antibody, crystallin gamma S antibody, Crygs antibody, CRYGS antibody

Background: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families, beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. This gene encodes a protein initially considered to be a beta-crystallin but the encoded protein is monomeric and has greater sequence similarity to other gamma-crystallins. This gene encodes the most significant gamma-crystallin in adult eye lens tissue. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.Synonyms: CRYGS, GRYG8, Gamma-S-crystallin, Gamma-crystallin S

Molecular Weight: 21007 Da

Gene ID: 1427

NCBI Accession: NP_060011