C4BPB antibody (Middle Region)

Catalog No. ABIN950920

This Rabbit Polyclonal antibody specifically detects C4BPB in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for C4BPB antibody (Middle Region) (ABIN950920)

Target: C4BPB (Complement Component 4 Binding Protein, beta (C4BPB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C4BPB antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-C4BPB Antibody

Binding Specificity: AA 124-153, Middle Region

Specificity: This antibody reacts to C4b-binding protein beta.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 124-153 amino acids from the Central region of human C4BPB

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for C4BPB

Target: C4BPB (Complement Component 4 Binding Protein, beta (C4BPB))

Alternative Name: C4b-Binding Protein beta

Background: This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.Synonyms: C4BPB

Gene ID: 725

NCBI Accession: NP_001017365

Pathways: Complement System