Endothelin 3 antibody (C-Term)

Catalog No. ABIN952025

The Rabbit Polyclonal anti-Endothelin 3 antibody has been validated for WB and EIA. It is suitable to detect Endothelin 3 in samples from Human.

Quick Overview for Endothelin 3 antibody (C-Term) (ABIN952025)

Target: Endothelin 3 (EDN3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Endothelin 3 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-Endothelin 3 Antibody

Binding Specificity: AA 175-205, C-Term

Specificity: This antibody recognizes Human Endothelin-3 (C-term).

Purification: Affinity Chromatography on Protein A

Immunogen: conjugated synthetic peptide between 175-205 amino acids from the C-terminal region of Human Endothelin-3. Genename: EDN3

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -80 °C for longer.

Target Details for Endothelin 3

Target: Endothelin 3 (EDN3)

Alternative Name: Endothelin-3

Background: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.Synonyms: EDN3, ET-3, ET3, HSCR4, MGC15067, MGC61498, PPET3, Preproendothelin-3, WS4B

Molecular Weight: 25454 Da

Gene ID: 1908

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones