Heat Shock Protein 90kDa beta (Grp94), Member 1 (HSP90B1) (AA 467-495), (Middle Region) antibody

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Antigen
Synonyms
ecgp, gp96, tra1, grp94, DDBDRAFT_0206450, DDBDRAFT_0215015, DDB_0206450, DDB_0215015, TRA1, HSP90B1, ERp99, GRP94, TA-3, Targ2, Tra-1, Tra1, endoplasmin, GP96, fb61d09, tra-1, wu:fb61d09, wu:fq25g01, ... show more
ecgp, gp96, tra1, grp94, DDBDRAFT_0206450, DDBDRAFT_0215015, DDB_0206450, DDB_0215015, TRA1, HSP90B1, ERp99, GRP94, TA-3, Targ2, Tra-1, Tra1, endoplasmin, GP96, fb61d09, tra-1, wu:fb61d09, wu:fq25g01, Grp94, ECGP, Gp96, ppk98, hsp108 show less
Epitope
AA 467-495, Middle Region
(67), (23), (21), (14), (14), (14), (13), (12), (10), (6), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(268), (138), (95), (69), (55), (31), (30), (30), (30), (28), (27), (27), (25), (24), (5), (3), (2), (2), (1), (1)
Host
Rabbit
(221), (66), (30), (18), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(18), (15), (13), (12), (9), (9), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(284), (139), (112), (99), (95), (87), (78), (66), (11), (7), (7), (3), (1), (1), (1)
Pubmed 2 references available
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Quantity 0.4 mL
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Immunogen KLH conjugated synthetic peptide between 467-495 amino acids from the Central region of human HSP90B1
Isotype Ig
Specificity This antibody recognizes Human Endoplasmin / HSP90B1 / TRA1 (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name Endoplasmin / HSP90B1 / TRA1 (HSP90B1 Antibody Abstract)
Background HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90B1 is an endoplasmic reticulum HSP90 protein. Other HSP90 proteins are found in cytosol (see HSP90AA1, MIM 140571) and mitochondria (TRAP1, MIM 606219) (Chen et al., 2005 [PubMed 16269234]).Synonyms: 94 kDa glucose-regulated protein, GRP94, Heat shock protein 90 kDa beta member 1, Tumor rejection antigen 1
Molecular Weight 92469 Da
Gene ID 7184
NCBI Accession NP_003290
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-Heat Shock Protein 90kDa beta (Grp94), Member 1 (HSP90B1) (AA 467-495), (Middle Region) antibody (ABIN952082) Flow cytometric analysis of A549 cells using Endoplasmin / HSP90B1 / TRA1 Antibody (C...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Heat Shock Protein 90kDa beta (Grp94), Member 1 (HSP90B1) (AA 467-495), (Middle Region) antibody (ABIN952082) Immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach t...
Western Blotting (WB) image for anti-Heat Shock Protein 90kDa beta (Grp94), Member 1 (HSP90B1) (AA 467-495), (Middle Region) antibody (ABIN952082) Western blot analysis of Endoplasmin / HSP90B1 / TRA1 Antibody (Center) in K562, A549...
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Suzuki, Kulkarni: "Extracellular heat shock protein HSP90beta secreted by MG63 osteosarcoma cells inhibits activation of latent TGF-beta1." in: Biochemical and biophysical research communications, Vol. 398, Issue 3, pp. 525-31, 2010 (PubMed).

Catalog No. ABIN952082
$401.50
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