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Integrator Complex Subunit 1 (INTS1) (N-Term) antibody

Details for Product No. ABIN952931, Supplier: Log in to see
Antigen
  • fa14a05
  • wu:fa14a05
  • wu:fa55a06
  • DDBDRAFT_0218704
  • DDBDRAFT_0234073
  • DDB_0218704
  • DDB_0234073
  • INTS1
  • INT1
  • NET28
  • 1110015K06Rik
Epitope
N-Term
19
2
2
Reactivity
Human
23
1
1
Host
Rabbit
23
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
20
16
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide selected from the N-terminal region of Human INTS1
Isotype Ig
Specificity This antibody recognizes Human INTS1 (N-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name INTS1 (INTS1 Antibody Abstract)
Background INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A, MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1, MIM 180680) and U2 (RNU2, MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).Synonyms: Int1, Integrator complex subunit 1, KIAA1440
Molecular Weight 244297 Da
Gene ID 26173
NCBI Accession NP_001073922
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Integrator Complex Subunit 1 (INTS1) (N-Term) antibody (ABIN952931) Western blot analysis of INTS1 Antibody  in human placenta tissue lysates (35ug/lane)...
Background publications Nusbaum, Mikkelsen, Zody et al.: "DNA sequence and analysis of human chromosome 8. ..." in: Nature, Vol. 439, Issue 7074, pp. 331-5, 2006 (PubMed).

Baillat, Hakimi, Näär et al.: "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II." in: Cell, Vol. 123, Issue 2, pp. 265-76, 2005 (PubMed).

Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).