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Phospholipase C beta 1 antibody (phospholipase C, beta 1 (phosphoinositide-Specific)) (C-Term)

Details for Product anti-PLCB1 Antibody No. ABIN954182, Supplier: Log in to see
Antigen
  • PLCB1
  • 3110043I21Rik
  • AI132408
  • Plcb
  • mKIAA0581
  • EIEE12
  • PI-PLC
  • PLC-154
  • PLC-I
  • PLC154
  • PLCB1A
  • PLCB1B
  • PLC'1
  • PLCbeta1
  • Phosphb
  • RATPHOSPHB
  • phospholipase C, beta 1 (phosphoinositide-specific)
  • phospholipase C, beta 1
  • PLCB1
  • plcb1
  • Plcb1
Alternatives
anti-Human Phospholipase C beta 1 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
C-Term, AA 1155-1184
15
3
3
1
1
1
1
1
1
1
Reactivity
Human
54
40
36
4
2
2
2
2
1
1
1
1
Host
Rabbit
51
4
1
Clonality
Polyclonal
Conjugate
This Phospholipase C beta 1 antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Western Blotting (WB)
33
18
16
13
11
5
3
3
1
1
Options
Supplier
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Immunogen KLH conjugated synthetic peptide between 1155~1184 amino acids from the C-terminal region of human PLCB1
Isotype Ig
Specificity This antibody recognizes Human PLCB1 (C-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name PLCB1 (PLCB1 Antibody Abstract)
Background The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11.Synonyms: 1-phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta-1, KIAA0581, PLC beta1, PLC-I, PLC-beta-1, Phosphoinositide phospholipase C-beta-1, Phospholipase C-I, Phospholipase C-beta-1
Molecular Weight 138567 Da
Gene ID 23236
NCBI Accession NP_056007
Pathways WNT Signaling, AMPK Signaling, Thyroid Hormone Synthesis, Inositol Metabolic Process, Regulation of Muscle Cell Differentiation
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-Phospholipase C beta 1 antibody (phospholipase C, beta 1 (phosphoinositide-Specific)) (C-Term) (ABIN954182) Flow cytometric analysis of HL-60 cells using PLCB1 Antibody (C-term) Cat.-No AP53333...
Western Blotting (WB) image for anti-Phospholipase C beta 1 antibody (phospholipase C, beta 1 (phosphoinositide-Specific)) (C-Term) (ABIN954182) Western blot analysis of PLCB1 Antibody (C-term) in HL-60 cell line lysates (35ug/lan...
Background publications Woodcock, Grubb, Filtz, Marasco, Luo, McLeod-Dryden, Kaye, Sadoshima, Du, Wong, McMullen, Dart: "Selective activation of the \b\" splice variant of phospholipase Cbeta1 in chronically dilated human and mouse atria."" in: Journal of molecular and cellular cardiology, Vol. 47, Issue 5, pp. 676-83, 2009 (PubMed).

Zhang, Kwon, Vogel, Filtz: "PI(3,4,5)P3 potentiates phospholipase C-beta activity." in: Journal of receptor and signal transduction research, Vol. 29, Issue 1, pp. 52-62, 2009 (PubMed).

Need, Attix, McEvoy, Cirulli, Linney, Hunt, Ge, Heinzen, Maia, Shianna, Weale, Cherkas, Clement, Spector, Gibson, Goldstein: "A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB." in: Human molecular genetics, Vol. 18, Issue 23, pp. 4650-61, 2009 (PubMed).