Patatin-Like phospholipase Domain Containing 3 (PNPLA3) (N-Term), (AA 108-137) antibody

Details for Product No. ABIN954228
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Antigen
Synonyms ADPN, C22orf20, iPLA(2)epsilon, Adpn
Epitope
N-Term, AA 108-137
(11), (8), (7), (7), (5), (3), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(25), (15), (1), (1), (1)
Host
Rabbit
(26), (6), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(34), (22), (6), (4), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 0.4 mL
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Catalog No. ABIN954228
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Immunogen KLH conjugated synthetic peptide between 108-137 amino acids from the N-terminal region of Human PNPLA3 Genename: PNPLA3
Isotype Ig
Specificity This antibody recognizes PNPLA3 (N-term).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Protein A Chromatography followed by peptide affinity purification.
Alternative Name PNPLA3 / ADPN
Background The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes.Synonyms: Acylglycerol O-acyltransferase, Adiponutrin, C22orf20, Calcium-independent phospholipase A2-epsilon, Patatin-like phospholipase domain-containing protein 3, iPLA2 epsilon
Gene ID 80339
NCBI Accession NP_079501
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Valenti, Alisi, Galmozzi et al.: "I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease." in: Hepatology (Baltimore, Md.), Vol. 52, Issue 4, pp. 1274-80, 2010 (PubMed).

Rotman, Koh, Zmuda et al.: "The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease." in: Hepatology (Baltimore, Md.), Vol. 52, Issue 3, pp. 894-903, 2010 (PubMed).

Santoro, Kursawe, DAdamo et al.: "A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents." in: Hepatology (Baltimore, Md.), Vol. 52, Issue 4, pp. 1281-90, 2010 (PubMed).

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