Transcription Factor A, Mitochondrial (TFAM) (C-Term), (AA 223-254) antibody

Details for Product No. ABIN955168
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Antigen
Synonyms tcf6, mttf1, mttfa, tcf6l1, tcf6l2, tcf6l3, mttfa-A, xl-mtTFA, MGC153358, zgc:153358, MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3, AI661103, Hmgts, mtTFA, tsHMG, Mttfa
Epitope
C-Term, AA 223-254
(12), (9), (7), (5), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(65), (21), (21), (14), (13), (13)
Host
Rabbit
(73), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(51), (29), (20), (20), (18), (17), (10), (9), (6), (3), (3), (1), (1), (1)
Pubmed 2 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN955168
357.50 $
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Immunogen KLH conjugated synthetic peptide between 223-254 amino acids from the C-terminal region of human TFAM
Isotype Ig
Specificity This antibody detects TFAM (C-term).
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein A column followed by peptide affinity purification
Alternative Name TFAM / TCF6
Background This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells.Synonyms: Mitochondrial transcription factor 1, MtTF1, TCF-6, TCF6L2, Transcription factor 6, Transcription factor 6-like 2, mitochondrial Transcription factor A
Gene ID 7019
NCBI Accession NP_003192
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Background publications Akhmetov, Popov, Missina et al.: "[Association of the mitochondrial transcription factor (TFAM) gene polymorphism with physical performance of athletes]." in: Fiziologiia cheloveka, Vol. 36, Issue 2, pp. 121-5, 2010 (PubMed).

Corneveaux, Myers, Allen et al.: "Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals." in: Human molecular genetics, Vol. 19, Issue 16, pp. 3295-301, 2010 (PubMed).

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