Topoisomerase (DNA) III beta (TOP3B) (C-Term), (AA 825-854) antibody

Details for Product No. ABIN955293
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Antigen
Synonyms TOP3B1
Epitope
C-Term, AA 825-854
(7), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(22), (8)
Host
Rabbit
(14), (8)
Clonality
Polyclonal
Application
ELISA, Western Blotting (WB)
(20), (14), (2), (2), (1), (1), (1)
Pubmed 4 references available
Catalog no. ABIN955293
Quantity 0.4 mL
Price
357.50 $   Plus shipping costs $45.00
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen KLH conjugated synthetic peptide between 825-854 amino acids from the C-terminal region of human TOP3B
Specificity This antibody detects TOP3B (C-term).
Purification Protein A column followed by peptide affinity purification
Alternative Name TOP3B
Background This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity, however, not all variants have been fully described.
Alternate names: DNA topoisomerase 3-beta-1, DNA topoisomerase III beta-1, TOP3B1
Gene ID 8940
NCBI Accession NP_003926
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Lehner, Sanderson: "A protein interaction framework for human mRNA degradation." in: Genome research, Vol. 14, Issue 7, pp. 1315-23, 2004 (PubMed).

Cho, Park, Han et al.: "Identification of the functional elements in the promoter region of human DNA topoisomerase IIIbeta gene." in: Biochimica et biophysica acta, Vol. 1679, Issue 3, pp. 272-8, 2004 (PubMed).

Lesch, Timmesfeld, Renner et al.: "Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies." in: Journal of neural transmission (Vienna, Austria : 1996), Vol. 115, Issue 11, pp. 1573-85, 2008 (PubMed).

Oliveira-Costa, Zanetti, Oliveira et al.: "Significance of topoisomerase IIIβ expression in breast ductal carcinomas: strong associations with disease-specific survival and metastasis." in: Human pathology, Vol. 41, Issue 11, pp. 1624-30, 2010 (PubMed).

Hosts (14), (8)
Reactivities (22), (8)
Applications (20), (14), (2), (2), (1), (1), (1)
Epitopes (7), (2), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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