SLC39A3 antibody (Middle Region)

Catalog No. ABIN955672

Product Details anti-SLC39A3 Antibody

Target: SLC39A3 (Solute Carrier Family 39 (Zinc Transporter), Member 3 (SLC39A3))

Binding Specificity: AA 113-142, Middle Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC39A3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: Recognizes SLC39A3 (Center).

Purification: Protein A column followed by peptide Affinity purification

Immunogen: KLH conjugated synthetic peptide between 113~142 amino acids from the Center region of Human SLC39A3 Genename: SLC39A3

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SLC39A3

Target: SLC39A3 (Solute Carrier Family 39 (Zinc Transporter), Member 3 (SLC39A3))

Alternative Name: Zinc Transporter ZIP3 / SLC39A3 (SLC39A3 Products)

Synonyms: AI845814 antibody, Zip3 antibody, ZIP3 antibody, wu:fc84e09 antibody, zgc:158334 antibody, solute carrier family 39 (zinc transporter), member 3 antibody, solute carrier family 39 member 3 antibody, Slc39a3 antibody, slc39a3 antibody, SLC39A3 antibody

Background: The zinc transporter ZIP3, also known as SLC39A3, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. Similar to knock-outs of ZIP1 and ZIP2, ZIP3-null mice have no phenotypic differences compared to wild-type mice. Only when ZIP1, ZIP2, and ZIP3 genes are all eliminated and these mutant mice are fed a zinc-deficient diet do abnormalities such as reduced embryonic-membrane bound alkaline phosphatase activity and abnormal development occur, indicating that the ZIP1-3 proteins play an important, noncompensatory role when zinc is deficient. More recent studies have shown that ZIP2 and ZIP3 are down regulated in human prostate adenocarcinomatous glands, and may be important in the retention of zinc in the cellular compartment.Synonyms: Solute carrier family 39 member 3, ZIP-3, ZIP3, Zrt- and Irt-like protein 3

Gene ID: 29985

NCBI Accession: NP_653165

Pathways: NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy