ADAM17 antibody (Isoform 1)

Catalog No. ABIN965510

The Rabbit Polyclonal anti-ADAM17 antibody has been validated for IHC. It is suitable to detect ADAM17 in samples from Human. There are 3+ publications available.

Quick Overview for ADAM17 antibody (Isoform 1) (ABIN965510)

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADAM17 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-ADAM17 Antibody

Binding Specificity: Isoform 1

Purification: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ADAM17 (a disintegrin and metalloproteinase domain 17 isoform 1 preproprotein)

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-ADAM17 antibody (ABIN965510)

Shao, Nadel: "Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 3, pp. 767-72, (2005) (PubMed).

Shao, Ueki, Nadel: "Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 20, pp. 11618-23, (2003) (PubMed).

Gschwind, Hart, Fischer, Ullrich: "TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells." in: The EMBO journal, Vol. 22, Issue 10, pp. 2411-21, (2003) (PubMed).

Target Details for ADAM17

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Alternative Name: ADAM17

Background: The ADAM17 (a disintegrin and metalloprotease (ADAM) domain 17) is a member of the ADAM protein family. Members of this family are membraneanchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The ADAM17 functions as a tumor necrosis factor-alpha converting enzyme.It binds mitotic arrest deficient 2 protein and also plays a prominent role in the activation of the Notch signaling pathway.

Pathways: Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus