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Adiponectin (ADIPOQ) (AA 55-69), (N-Term) antibody

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Antigen
Epitope
AA 55-69, N-Term
54
46
27
13
13
11
11
10
7
6
6
6
5
5
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
472
158
112
30
15
4
4
3
1
1
Host
Rabbit
370
231
16
10
4
3
Clonality
Polyclonal
Conjugate
Un-conjugated
65
28
24
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
414
365
106
69
45
35
33
31
29
14
11
9
8
2
2
2
2
1
1
1
1
1
1
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to residues 55-69 of human ADIPOQ(Adiponectin precursor)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name ADIPOQ
Background ADIPOQ (Adiponectin) is an important negative regulator in hematopoiesis and immunesystems. ADIPOQ may be involved in ending inflammatory responses through its inhibitory functions. ADIPOQ inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. It inhibits TNF-alpha-induced expression of endothelial adhesion molecules. ADIPOQ is involved in the control of fat metabolism and insulin sensitivity. Defects in ADIPOQ are the cause of adiponectin deficiency. The result is a very low concentration of plasma adiponectin. The decreased adiponectin plasma levels are associated with obesity insulin resistance, and diabetes type 2.
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Zhang, Henzel: "Signal peptide prediction based on analysis of experimentally verified cleavage sites." in: Protein science : a publication of the Protein Society, Vol. 13, Issue 10, pp. 2819-24, 2004 (PubMed).

Yamauchi, Kamon, Waki, Terauchi, Kubota, Hara, Mori, Ide, Murakami, Tsuboyama-Kasaoka, Ezaki, Akanuma, Gavrilova, Vinson, Reitman, Kagechika, Shudo, Yoda, Nakano, Tobe, Nagai, Kimura, Tomita, Froguel et al.: "The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. ..." in: Nature medicine, Vol. 7, Issue 8, pp. 941-6, 2001 (PubMed).

Yokota, Oritani, Takahashi, Ishikawa, Matsuyama, Ouchi, Kihara, Funahashi, Tenner, Tomiyama, Matsuzawa: "Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages." in: Blood, Vol. 96, Issue 5, pp. 1723-32, 2000 (PubMed).

Ouchi, Kihara, Arita, Okamoto, Maeda, Kuriyama, Hotta, Nishida, Takahashi, Muraguchi, Ohmoto, Nakamura, Yamashita, Funahashi, Matsuzawa: "Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway." in: Circulation, Vol. 102, Issue 11, pp. 1296-301, 2000 (PubMed).

Nakano, Tobe, Choi-Miura, Mazda, Tomita: "Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma." in: Journal of biochemistry, Vol. 120, Issue 4, pp. 803-12, 1997 (PubMed).

Berg, Egner, Lowe: "Mechanism of F factor-enhanced excision of transposon Tn5." in: Gene, Vol. 22, Issue 1, pp. 1-7, 1983 (PubMed).

Product cited in: Arita, Kihara, Ouchi, Takahashi, Maeda, Miyagawa, Hotta, Shimomura, Nakamura, Miyaoka, Kuriyama, Nishida, Yamashita, Okubo, Matsubara, Muraguchi, Ohmoto, Funahashi, Matsuzawa: "Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity." in: Biochemical and biophysical research communications, Vol. 257, Issue 1, pp. 79-83, 1999 (PubMed).

Saito, Tobe, Minoshima, Asakawa, Sumiya, Yoda, Nakano, Shimizu, Tomita: "Organization of the gene for gelatin-binding protein (GBP28)." in: Gene, Vol. 229, Issue 1-2, pp. 67-73, 1999 (PubMed).

Schäffler, Orsó, Palitzsch, Büchler, Drobnik, Fürst, Schölmerich, Schmitz et al.: "The human apM-1, an adipocyte-specific gene linked to the family of TNF's and to genes expressed in activated T cells, is mapped to chromosome 1q21.3-q23, a susceptibility locus identified for ..." in: Biochemical and biophysical research communications, Vol. 260, Issue 2, pp. 416-25, 1999 (PubMed).