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Angiopoietin 1 antibody (ANGPT1) (Middle Region)

Details for Product anti-ANGPT1 Antibody No. ABIN965551, Supplier: Login to see New
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Antigen
Synonyms ang1, wu:fc76g06, ANG-1, angpt1, MGC80788, 1110046O21Rik, Ang-1, Ang1, AGP1, AGPT, ANG1, Agpt, Agpt1, DHCR14A, NET47
Alternatives
Epitope
Middle Region
(26), (20), (13), (10), (9), (8), (8), (7), (6), (6), (6), (6), (5), (4), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(128), (65), (36), (19), (18), (5), (2), (1)
Host
Rabbit
(156), (15), (8), (1)
Clonality
Polyclonal
Conjugate
This Angiopoietin 1 antibody is un-conjugated
(20), (14), (7), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(137), (92), (31), (31), (18), (15), (11), (5), (3), (2), (2), (1)
Pubmed 3 references available
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Quantity 100 μg
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Immunogen A synthetic peptide corresponding to a sequence in the middle region of human ANG1 , different from the related mouse sequence by two amino acids, and different from the related rat sequence by only one amino acid.< br/>Immunogen was affinity purified.
Isotype IgG
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for Angiopoietin-1 (ANGPT1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Alternative Name Angiopoietin-1(ANG-1) (ANGPT1 Antibody Abstract)
Background Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1. Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Angiopoietin-1 seems to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22. 3-q23 and 8p23.
Pathways RTK Signaling
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative Sodium azide, Thimerosal (Merthiolate)
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Product cited in: Compston: "Selective oestrogen receptor modulators: potential therapeutic applications." in: Clinical endocrinology, Vol. 48, Issue 4, pp. 389-91, 1998 (PubMed).

Cheung, Stewart, Marsden: "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23." in: Genomics, Vol. 48, Issue 3, pp. 389-91, 1998 (PubMed).

Background publications Suri, Jones, Patan et al.: "Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis." in: Cell, Vol. 87, Issue 7, pp. 1171-80, 1997 (PubMed).

Catalog No. ABIN965551
$330.00
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